The effects of alcoholic extract of Marrubum vulgare on hormonal parameters in female rat model of polycystic ovarian syndrome

Polycystic ovarian syndrome (PCOS) is a disorder which causes disorder in the ovulation and infertility in women. This study was design to investigate the effects of alcoholic extract of white Marrubum vulgare plant on the hormonal parameters model of polycystic ovarian syndrome in the adult female rats. In this experimental study، 48 adult female rats from wistar race with approximate weight of 180 to 200 grams were evaluated. The rats were divided into 6 groups of 8 numbers each randomly. Control group، sham group، experimental group 1 received 500 mg/kg of oral extract for 21 days، experimental group 2 PCOS، experimental group 3 (PCOS+500 mg/kg) and experimental group 4 (PCOS +1000mg/kg) were fed extract for 21 days. On the 22nd day، blood samples were collected from all the groups for measuring serum levels of LH، FSH، testosterone، estradiol and progesterone hormones using RIA. LH hormone serum level in the group of “PCOS+1000mg/kg” showed a significant reduction compared to PCOS. FSH hormone level did not show any difference in any groups، compared to control group and PCOS. The level of estradiol hormone in the group of PCOS+500mg/kg، PCOS +1000mg/kg revealed a significant reduction، compared to PCOS. Testosterone hormone level in the group of PCOS+1000mg/kg showed a significant reduction in comparison to PCOS، and finally the level of progesterone in the group of PCOS +500mg/kg and PCOS +1000mg/kg exhibited a significant reduction، compared to PCOS. The results indicate that alcoholic extract of white Marrubium Vulgare improves hormonal parameters in polycystic ovarian syndrome.