Evaluation of angiotensin - converting inhibitors before coronary bypass surgery and their effects on hemodynamics parameters and need for vasoactive drugs

According to the previous theories based on the issue that anti-hypertensive drugs should be withdrawn before surgery, nowadays it is accepted that some drugs effectively control systemic blood pressure to assure its desirable therapeutic control. So in this study, the efficacy of angiotensin inhibitors before the CABG surgery onhemodynamic changes was surveyed.

In this research, 54 patients were selected from those hospitalized in the cardiac surgery ward of Ahvaz Golestan Hospital by random sampling. They were divided into two groups of 27 each. The first group did not use angiotensin inhibitor to control blood pressure but the second group consumed it. In these groups, the needed amount of vasoactive drug for the patients, the efficacy of angiotensin inhibitor on hypotension rate before, during, and after surgery, and the neededamount of vasopressor drugs were surveyed.

The two experiments and control groups did not have significant differences from the viewpoints of demographic characteristics such as age, sex, and weight, and hemodynamic changes of SaO2 and PR before, during, and after surgery.Nevertheless, they had significant differences from the viewpoints of changes in minimum and maximum blood pressures in different time sections.

Using angiotensin inhibitor drugs can effectively reduce the blood pressure before, during, and after CABG surgery in the patients of the experimental group compared to the control group.