The Effect of two Different Doses of Propofol Infusion on Cardiovascular Responses in Patients Candidate for Nasal Septoplastic Surgery

There is no general consensus on the minimum dose of propofol for maintenance of anesthesia. The purpose of this study was to determine the effect (s) of two different doses of propofol on cardiovascular responses in patients undergoing Septoplasty surgery. In the present clinical-trial study، fifty-eight patients (15 to 55 years) candidate for nasal Septoplasty were randomly divided into two groups of A (propofol infusion dose 50µg/kg/min) and B (propofol infusion dose 100µg/kg/min). After induction of anesthesia and intubation، propofol infusion was started with two different doses. Systolic، diastolic and mean arterial blood pressures were measured at 0، 2، 5، 10، 15، 20، 30، 45 and 60 minutes after initiation of infusion. The depth of anesthesia during the surgery and wake-up time was evaluated. The data were analyzed by independent sample t-test، Mann-Whitney U test، repeated measure and Freidman. Wake up time in group A and B was (28. 71±3. 19) and (31. 00±5. 29) min respectively which no significant differences were observed between the two groups. Changes in heart rate and systolic blood pressure، diastolic and mean arterial at different minutes in each group compared with the other two groups showed no significant difference (p> 0. 05). Increasing dose of propofol from 50µ/kg/min to 100µ/kg/min does not affect the depth of anesthesia، cardiovascular responses and wake up time، so a lower dose of propofol infusions is recommended during general anesthesia.