Comparison of Exercise-Induced Inflammatory Response in Serum and Saliva of Healthy Men

This study was conducted to compare of inflammatory markers response in serum and saliva of healthy men following an exhaustive exercise test. Twenty two volunteer healthy men (aged 20-30 years and body fat 10-16%) in a quasi-experimental، single group design participated in Bruce exercise test. Serum and saliva samples were collected immediately before and after the exercise test. C-reactive protein (CRP) and interleukin-6 (IL-6) were determined by Immunoturbidimetric and ELISA methods، respectively. Data were expressed as mean (±SD) and analyzed by paired t-test and Spearman at α≤0. 05. The serum and saliva CRP and IL-6 were significantly increased (P<0. 05) after the exercise test. Moreover، the correlation between serum and salivary samples for CRP (rPre=0. 82 and rPost= 0. 88) and IL-6 (rPre=0. 42 and rPost= 0. 54) was significantly positive (P<0. 05). According to the present results، it can be concluded that saliva CRP and most likely IL-6 samples a suitable and noninvasive alternative for use in order to evaluate exercise-induced systemic inflammation.