Comparison the Effect of Zinc Chloride and Aluminum Chloride in Controlling Liver Bleeding: an Animal Model Study

Introduction & The control of parenchymal hemorrhage especially in liver parenchyma, is still one of the challenges surgeons face saving the patients’ lives, despite progresses in surgical science. Furthermore there is a competition between the researchers in this field to introduce a more effective method. This study aimed at comparing the hemostatic effect of zinc chloride and aluminum chloride on controlling the bleeding from liver parenchymal tissue. In this animal model study, 60 male Wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured, using zinc chloride and aluminum chloride of different concentrations (15%, 25%, and 50%). Finally, the collected data were entered into SPSS software and analyzed using the one-way Anova test. In all groups we had complete hemostasis. The hemostasis time of zinc chloride concentration groups was significantly less than that of the aluminum chloride group. Zinc chloride is more effective than aluminum chloride, as a hemostatic agent, in controlling liver hemorrhage, in our animal model study.