The effect of influenza vaccine injection on proinflammatory and anti-inflammatory markers in immature boy gymnasts

Introduction And Although، the effect of the acute exercise prior to vaccination on improved the immune system response was investigated، the immune response to an exercise period is unclear. The aim of this study was to determine the effect of influenza vaccine on pre-inflammatory and anti-inflammatory markers in prepubertal boy gymnasts. Thirty boy gymnasts divided into 2 groups; vaccine group and control. The exercise protocol consisted of intensity 60-80% of maximum heart rate، 3 days per week، for 8 weeks. Blood samples were obtained in first، 4 and 8 weeks to determine of IL-6، IL-10 and IFN-γ serum concentrations. The results showed that IL-6 and INFγ after four weeks decreased in two groups (P=0. 000، P=0. 001 respectivly). Significant difference in 8th week in the only vaccine group was observed. Decreasing trend of INFγ was continued in the control group، however، this decrease was not significant. Significant difference in INFγ was observed in 4th and 8th weeks in the vaccine group. In compared with pre-exercise، IL- 10 was increased in two groups (P=0. 006). Significant difference in IL-10 was observed in the 4th and 8th weeks، in two groups. These data demonstrate that influenza vaccination has a significant effect on immune system and inflammatory state in prepubertal boy gymnasts.