Effects of 3 Resistance Training Programs on Serum Vaspin, hs-CRP and TNF-α Concentrations in the Streptozotocin-induced Diabetic Rats

Backgrand & Vaspin is a novel adipokine that may exert an anti-inflammatory role، and has potentialinsulin-sensitizing properties. However، there is limited information available regarding the effect of exercise training on serum vaspin concentration. The purpose of this study was to investigate the effects of 3 resistance training programs on serum vaspin levels and some inflammatory markers in diabetic rats. Forty male Wister rats (288 ± 19 g) were randomly divided into five groups: non-diabe􀀟c control، diabe􀀟c control، diabe􀀟c trained with 50% body mass (BM)، diabe􀀟c trained with 100% BM، and diabetic trained with progressive load. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) at a dose of 55 mg/kg. The exercise groups were subjected to their resistance training program with the use of a ladder (3 days/wk، for 4 wk). Body weight، serum Vaspin، Insulin، high sensitivity C-reactive protein (hs-CRP)، tumor necrosis factor (TNF) -α،and fasting glucose were measured. Four weeks resistance training increased serum vaspin levels، however it was significant only in diabe􀀟c trained rats with 50% BM. TNF-α concentration significantly decreased in diabetic trained rats with progressive load. Serum CRP levels in all trained groups were significantly lower compared with diabetic control group. This study indicated that resistance training with suitable volume and intensity couldimprove serum vaspin and some of inflammatory markers including TNF-α and CRP levels; hence this type of exercise may be an efficient strategy to protect against some diabetic complications. However، to determine the underlying mechanisms of vaspin alterations and functions in response to exercise، further research is required.