The Effect of Feeding Glucose on AGRP, Insulin and Glucose Levels after a Session Circular Resistance Activities in Young Free Wrestlers

AGRP is a neropeptide released from Arcuate Neucleus of hypothalamus which plays an important role in energy balance، weight control and feeding. It has been reported that negative energy balance circumstance causes AGRP level to increase. It is also stopped by the creation of positive energy balance circumstance (energy sources restoration). The purpose of this study is to evaluate the effect of oral sugar (glucose) consumption after circular resistance activities on AGRP، insulin and plasma glucose. For this purpose، 16 young free wrestlers (age، 22. 29 ±. 9 weight 75. 45 ± 12. 9 and body mass index BMI 26. 23±2. 60) were randomly selected and then randomly divided into two sugar (1 gr per kg body weight n=8) and water groups (n=8). The subjects were asked to run wrestling Technique Based Circuit Exercise (WTBCE). Blood sampling was obtained in three stages، before، immediately and after 90 minutes after feeding by glucose solution. For the measurement of plasma AGRP commercial ELISA kits were used. The data was analyzed by repeated measurements and LSD test in the significant level of P <0. 05. According to the results، a significant difference was observed in plasma insulin levels (F=40. 43، P<. 001)، AGRP (F=1. 12، P<. 001) time points، and time between groups. This changes in plasma glucose levels only were significant in time point (F=36. 6، P<. 033). The statistical analysis showed that the sugar group has lower AGRP levels and higher levels of insulin than water group. Therefore، increasing plasma AGRP levels immediately after exercise indicates that the designed acute activity was able to produce energy consumption and negative energy balance. It has also been shown that feeding of oral glucose (1 gr per kg body weight) caused increasing plasma glucose and increasing releasing of insulin could inhibit increasing levels of AGRP created due to sever activity. Thus، it can be claimed that elevatedlevels of AGRP in severe activity increases appetite which could be necessary to rebuild lost energy source.