Association between Serum HSP27 in Behcet's Disease Patients, with and without Uveitis

Behcet''s disease (BD) is an autoimmune disease، which can affect multiple systems in the human body. Recently، the effects of serum heat shock protein (HSP27) level and antibodies against it have been demonstrated in Behcet''s etiology and pathogenesis. This study aimed to determine the serum levels of HSP27 and high-sensitivity C-reactive protein (hs-CRP) in BD، and their relationship with uveitis in these patients In the current cross-sectional study، the sample size was calculated as 94 individuals. The subjects were divided into three groups: patients with Behcet’s uveitis (BD+U)، BD patients without uveitis (BD-U)، and those with idiopathic uveitis. The serum levels of HSP27 and hs-CRP were compared among the three groups. The serum HSP27 level was measured، using ELISA technique. The mean serum HSP27 level was 28. 81±7. 593، 31. 78±6. 841، and 24. 07±7. 095 in BD-U، BD+U، and idiopathic uveitis patients، respectively. These results indicated that there was a significant difference between the three groups regarding serum HSP27 level (F=8. 118) (P=0. 001). According to the results، there was a significant difference in HSP27 level in BD+U and idiopathic groups; therefore، serum HSP27 level can be a sensitive marker for the diagnosis of Behçet''s uveitis Acknowledgment: This study was supported by Rheumatic Diseases Research Center and Mashhad University of Medical Sciences، further more there was not any conflict of interest in doing this research