Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome in childhood: A case report and review of literature

The term SAPHO (synovitis, acne,pustulosis, hyperostosis, and osteitis) syndrome was proposed in anattempt to unify the group of clinical conditions previouslydescribed as separate entities with hyperostosis of anterior chestwall, synovitis, and multifocal aseptic osteomyelitis, observed inassociation with dermatologic conditions such as palmoplantarpustulosis, severe acne and hidradenitis suppurativa. Controversyremains regarding whether chronic recurrent multifocal osteomyelitis(CRMO) and SAPHO occur on a spectrum or are separate entitiesconsidering that they affect the patients with diferent age groupsand they involve different bones. Normally CRMO is expected to beseen during childhood whereas SAPHO in adults. However, there havealso been recent reports of CRMO occurring in adults and SAPHOsyndrome occurring in children. Herein we report a 12-year-old girldiagnosed with SAPHO syndrome who was treated successfully during herfollow up at our clinic.