Reversible therapy-related dysplastic hematopoiesis following Beta Interferon Therapy in Multiple Sclerosis Patients: Report of 2 Cases

Interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (MS). The most frequent systemic adverse effects are flulike symptoms. Laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. Myelodysplastic Syndrome (MDS) refers to a spectrum of hematological disorders which can occur in different situations. Several hematological abnormalities have been reported following interferon therapy. We report two cases of secondary MDS after long term interferon therapy by using the laboratory data and bone marrow results. Both of our cases were reversible; although treatment with IFN6-1a and-1b is safe and well tolerated in the majority of population, we should be careful about this premalignant hematological disorder.