Simultaneous Voltammetric Determination of Norepinephrine, Ascorbic Acid and Uric Acid by TTAB Modified Carbon Paste Electrode

A cationic surfactant tetradecyl trimethyl ammonium bromide modified carbon pasteelectrode (TTABMCPE) was fabricated and the electrochemical behavior of norepinephrine at the modified electrode was investigated by cyclic voltammetric and differential pulse voltammetric techniques. A well-defined oxidation peak was observed at 174 mV and the significant increase in peak current at modified carbon paste electrode compared to bare carbon paste electrode was obtained. The effect of scan rate on the oxidation of norepinephrine was examined and it was found that the anodic peak current was proportional to the concentration of norepinephrine in the range from 0.10 μM to 4 μM. Comparedwith other reported electrochemical method; this new sensingmethod has higher sensitivity, rapid response and extreme simplicity. TTABMCPE was used for the simultaneous determination of nor norepinephrine, ascorbic acid and uric acid.The analytical performance of this biosensor has been evaluated for the detection of norepinephrine in injection sample.