Application of Membrane Selective Electrodes for the Determination of Azelastine Hydrochloride in the Presence of its Alkaline Degradant in Eye Drops and Plasma

Azelastine Hydrochloride (AZT) was described by using the ion association complex between these drugs with either sodium tetraphenyl-borate (TPB) or ammonium reineckate (RNC) counter ions. The performance characteristics of the sensors were evaluated according to IUPAC recommendations, reveal a fast, stable and linear response over the concentration range 10-5- 10-2 M for AZT. The sensors are used for determination of AZT in eye drops and plasma. The developed method was found to be simple, accurate and precise when compared with the Manufacturer method.