Effect of the Extract of Aloe vera on the Pentylenetetrazol Induced Seizure in Male Mice

Epilepsy is the most common neurological disorder after stroke. Despite various anticonvulsants, researches continue to discover new drugs with better efficacy and less side-effects. Various herbs and natural substances with different properties are appropriate fields for such researches. This study investigated the effects of Aloe vera latex on seizure in male mice. Two groups of mice (n=8) and placebo were tested. The control group received Saline and the experimental group received Aloe vera latex (15, 25 and 50mg/kg) and half an hour later PTZ (80mg/kg) was injected intraperitoneally. Immediately after injection of PTZ, seizure threshold and duration of seizure were recorded. Data were analyzed by ANOVA and Tukey's test. p<0.05 was considered statistically significant. The group receiving a 25mg/kg dose of Aloe vera latex showed a significant increase in seizure threshold and a significant decrease in duration of seizure as compared with placebo group receiving saline (p<0.05). The results of this study indicated the anticonvulsant effect of Aloe vera latex.