Effect of Hydroalcoholic Extract of Allium hirtifolium on some Biochemical Factors Following Gentamicinin in Mice

Some studies on the toxicity of gentamicin-induced oxygen metabolites involved would know. On the one hand due to the antioxidant properties of garlic aim of this study was to investigate the effect of shallot extract (Allium hirtifolium Boiss) after gentamicin administration in mice. The experimental study on 32 mice weighing 30±5 in 4 groups each 8 mice, 1 or control group receiving distilled water (0.7 ml), Group 2: treated with gentamicin dose 80 mg/kg to create Hepatic and renal impairment and groups 3 and 4, respectively, shallot extract in doses of 40 mg/kg and of 80 mg/kg with gentamicin (80 mg/kg) performed. Experimental period in all groups was 10 days. At the end of the experiment after 24 hours from the last injection, biochemical parameters, urea, creatinine, uric acid, alkaline phosphatase, lactate dehydrogenase, aspartate amino transferase and alanine amino transferase were measured by Routine enzymatic and laboratory methods. Administration of gentamicin combined with shallots (40 mg/kg) decreased alkaline phosphatase activity (92±40.36) compared with group 2 (158.73±40.36) and Group 1 (157.40±44.07) (p<0.05). The simultaneous administration of gentamicin- shallots in groups 3 (52.50±17.94) and 4 (42.29±17.42) caused a decrease in blood urea compared with group 2 (59.18±13.17) has been (p>0.05). Results showed that shallot extract may reduce biochemical factors resulting from the use of gentamicin.