Matrix Metalloproteinases and Breast Cancer

Context: Matrix metalloproteinases (MMPs) are multigene family structurally and functionally related endoproteinases. The basic action of 23 types of MMPs collectively involves degradation of virtually every component of extracellular matrix (ECM) in tumor cells migration and metastasis process. This review article aimed at surveying MMPs specific role in various steps and cellular pathways involving in breast carcinogenesis.Evidence Acquisition: This review article compromised published articles in PubMed and GoogleScholar according to keywords since 1988. Based on the recent researches, certain MMPs play critical role in breast cancer initiation, invasion, and metastasis. They can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. In summary, the results of this review article provide rational evidences for applying in human clinical trials toward MMPs in breast cancer therapies.