Study Effects of Hydroalcoholic Extract of Medicago sativa in the Treatment of Acetic Acid Induced Gastric Ulcer in Rats

Inroduction & Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat. In this experimental study, 60 wistar rats weighting approximately (200-250g) were randomly divided into 4 groups; control, sham(normal salin), experiment 1 (extract of dose 250 mg/kg body weight) and experiment 2 (extract of dose 500 mg/kg body weight). Rats were deprived of food and then underwent surgeryand gastric wasby injecting60% acetic acid after 4,7,10,14 days gavage, the rat's stomach out and then measuring the wound and fixed with 10% formalin, the passage of the tissue section was stained And the number of neutrophils, macrophages and fibroblasts were counted.Results showed that the hydroalcoholic extract of Alfalfacaused a significant increase in gastric ulcer healing in experimental groups 1 and 2 (PAlfalfahydroalcoholic vegetive arial organs extract is effective in the treatment of peptic ulcer induced by acetic acid.