Prevalence of Class 1 Integron and Antibiotic Resistance among Pseudomonas Aeruginosa Isolated from Patients Admitted to the Burn Unit at Taleghani Hospital in Ahvaz

Pseudomonas aeruginosa is one of the major etiologic agents of nosocomial infection among burn patients that has high resistance to antibiotics. Integrons can extend antibiotic resistance genes among bacteria. The aim of this study was to investigate the antibiotic resistance pattern and the prevalence of integron among P. aeruginosa isolates. In this cross-sectional study، a total of 73 P. aeruginosa isolated from burn wound infections among hospitalized patients in Ahvaz Taleghani hospital. Antibiotic resistance pattern of these bacteria was investigated to 9 antibiotics by Disk Agar Diffusion method. Polymerase chain reaction (PCR) method was used to investigate the prevalence of class 1، 2 and 3 integrons. The data were analyzed by Chi-square test. A P-value of <0. 05 was considered as a statistical significance level. The most antibiotic resistance level was seen against ofloxacin (94. 5%)، aztreonam (94. 5%)، and ceftazidime (93. 6%). Fifteen isolates of P. aeruginosa were resistance to all of the antibiotics. The study of molecular results showed that class 1 integron was detected in 35. 6% of isolates، while none of them harbored class 2 and 3 integron. The rates of antibiotic resistance in pseudomonas aeruginosa to antibiotics such as ceftazidime، oflaxacin، aztreonam، cefepime، and ceftriaxone is very high. Although، class 1 integron were detected in 35. 6% of isolates، there was no statistically significant differences between the presence of integron and resistance to a specific antibiotic، that it shows the role of the other antibiotic resistance mechanisms among pseudomonas aeruginosa.