The effect of endurance Activity on left ventricle Hand2 gene expression in wistar male rat

Endurance activity causes changes in the expression of some genes and induces hypertrophy in heart، Meanwhile Hand2 gene is changed in response to pathological hypertrophy of the heart، so the aim of this study was to investigate the effect of endurance activity on Hand2 gene expression in left ventricle. For this purpose، 14 rats (male wistar، 113±20g، age five weeks) under controlled conditions (temperature، light/dark (12:12) cycle، with ad Libitum access to food and water) were housed and randomly divided into control and Experimental groups، the experimental group performed 14 -weeks endurance training on motorized treadmill، and then were anesthetized and sacrificed 48 hours after the end of the last session. The left ventricle of the heart was removed. Real time RT-PCR method was used to determine the expression levels of Hand2 in the left ventricle. the obtained data were evaluated using t-test. The results showed، the mean of left ventricle Hand2 gene expression increased in experimental group significantly (P=0. 007) than control group. It seems، Hand2 gene influence on created the type of hypertrophy.