Does APOA-II polymorphism interact with the association of obesity and serum inflammatory biomarkers in type 2 diabetic patients?

To investigate the relationship between serum IL 18, PTX3 and hs-CRP levels with BMI and abdominal obesity and also the interaction between genetic variants of Apo A-II and obesity on the levels of these factors in type 2 diabetes patients (T2D).Design: A comparative cross-sectional studySetting: 21 diabetes centers in Tehran Subjects: 180(35-65years) T2D patients were divided into two groups of 90 obese (BMI≥30) and 90 non-obese (BMI<30) according to the BMI with equal numbers of each genotypes of Apo A-II: 30 TT, 30 CC and 30TC. Serum IL 18, PTX3 and hs-CRP concentrations were compared between two obese and non-obese groups and between subjects with and without central obesity. To investigate the interaction of APO A-II genetic variants and BMI with inflammatory factors General Linear Model was used. After adjusting data with confounding factors, the mean of serum PTX3 was significantly lower (p<0.05) in the obese diabetes than non-obese diabetes subjects. Moreover, obese diabetes had higher serum hs-CRP level that on-obese subjects (p<0.01). No significant interaction between APO A-II 256 T>C polymorphism and BMI on inflammatory biomarkers was observed. There was a significant difference in inflammatory markers (PTX3 and hs-CRP concentration) between obese and non-obese diabetes. In addition, there was no interaction of APO A-II 256 T>C genotypes and BMI on inflammatory markers. Weight control may be recommended to modulate inflammation and its complications in obese patients.