Investigation of effective factors in preparation of polybutyl cyanoacrylate nanoparticles by emulsion polymerization

Aim and In recent decades, drug carriers in nano scale have been focus of attentions. In last two decades, cyanoacrylate nanoparticles have been widely studied as drug nanocarriers. In this work, production of polybutyl cyanoacrylate (PBCA) nanoparticles by emulsion polymerization has been investigated. polybutyl cyanoacrylate nanoparticles were produced by emulsion polymerization using 70 KDa dextran as stabilizer. Nanoparticles were described by Zeta sizer, scanning electron microscope and light microscope. Effect of polymerization factors on size and distribution of particles, was studied. Such factors include 70 KDa dextran, polysorbate-80, concentration of H+ ion, polymerization time, temperature and sonication. This study indicates that a definite portion of stabilizer is essential for the production of nanoparticles. This concentration was recognized to be 2%. Effect of H+ ion was considerable as a sharp decrease was observed in pH 4. In comparison with room temperature, higher size and distribution of nanoparticles was gained in temperature of 50 °C. Effect of polysorbate-80 in concentration of 0.001% on nanoparticles was evaluated to be positive. Furthermore, increasing polymerization time from 5.5 to 18 hours resulted in synthesis of more appropriate nanoparticles. The results illustrate that nanoparticles properties depend on various factors and manipulation of such factors can result in desirable properties. PBCA nanoparticles are under the influence of various factors and we can make an acceptable and desirable nanoparticle by their proper manipulation.