Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats

Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats. In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by one-way ANOVA. Findings showed a significant reduction (P<0.05) of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract, 20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase (P<0.05) in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil. The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats.