Salivary lipid peroxidation in patients with oral lichen planus

Oral Lichen Planus (OLP) is an inflammatory condition with unknown etiology. Reactive oxygen species (ROS) and free radicals may play an important role in the pathogenesis of this disease. The aim of this study was to compare salivary lipid peroxidation in patients with oral lichen planus with healthy subjects. This case-control study was conducted in Zahedan School of Dentistry during 2014-15. Unstimulated saliva samples were collected from 30 patients with OLP and 30 age and gender-matched healthy controls and were transferred to the laboratory. Salivary lipid peroxidation products were measured using TBARS (thiobarbituric acid reactive substance) method. Data were analyzed using Mann-Whitney U test. Salivary lipid peroxidation in patients with OLP was significantly higher than healthy controls (1. 57±0. 63 µM vs. 1. 2 ± 0. 77µM). Mean Salivary lipid peroxidation in women with OLP was significantly higher than healthy women (1. 67±0. 67 µM vs. 1. 16±0. 82 µM). With regards to the results، it seems that lipid peroxidation in patients with OLP is higher than healthy subjects.