Evaluation of the proinflammtory role of resistin and C reactive protein (CRP) in patients with type 2 diabetes: effect of aerobic and resistance exercise

Risk of premature mortality and cardiovascular disease in people with diabetes are twice that of non-diabetics, but the role of inflammatory biomarkers such as resistin and CRP that used for prediction of these disease is unknown after exercise. So, the aim of the present study was to examine the proinflammatory role of resistin and CRP, after aerobic and resistance exercise in patients with type 2 diabetes. 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 2 experimental groups of aerobic training (n = 14), resistance training (n = 13) and control group (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate), the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples to determine the levels of resistin, CRP, insulin, HbA1c and glucose in pre-and post-tests were collected. Statistical analysis was performed using, Dependent t test, one way Anova, Pearson correlation with spss software (version 21). According to statistical analysis of the results, Resistin and CRP increase and decrease, respectively, in both exercise training groups, anthropometric measurements(weight, BMI, %Body fat and Waist to hip ratio) only decreased in aerobic group, insulin resistance only decreased in resistance group and glycated hemoglobin and glucose decreased in both training groups (p≤0/05). Also there was a significant inverse correlation between resistin and CRP in post-test of resistance group (P≤0/05). Due to changes in resistin and CRP levels after exercise, it dose not seem that resistin causes insulin resistance and be a predictive factor for cardiovascular disease.