Study of antinociceptive effects of Pelargonium geraveolens L. leaves hydroethanolic extract in male mice

Pain is a somatosensory sense that as an indicator to diagnoses for diseases . Pelargonium graveolens is known as a medicinal plant with use in traditional medicine. The aim of this study is to evaluate the analgesic effect of Pelargonium graveolens leaves extract (PGE) in male mice.
Material and In this experimental study, 42 male mice were divided in 6 groups (n=7). The control group(taking normal saline,0.25 ml, i.p), morphine group( 1mg/kg, i.p), treated groups with PGE at doses of 100, 200 and 600mg/kg and group induced with naloxone (0.1mg/kg, i.p) 200mg/kg of PGE. In order to evaluate the analgesic effects of PGE the tail flick and writhing tests were used. The data for each test were compared with One-way ANOVA and Tukey's post test.
Our results showed that PGE (200 and 600 mg/kg) increased pain thershold compared with control group in writhing and tail flick test significantly (P The PGE has anitinociceptive effects in male mice. This analgesic effect of Pelargonium graveolens extract probably related to its flavonoids composition which has effect on opioid system.