The Effect of Ethanolic Extracts of Petroselinum crispum Leaves on Histopathological and Activity of Liver Enzymes in Streptozotocin-Induced Diabetic Rats

According to the progress of diabetes and the use of alternative herbal medicines, in this study, the effect of Petroselinum crispum parsley leaf hydroalcoholic extract on histopathological and liver enzymatic activity were examined.
In this study, 60 male wistar rats with the weight range of 250-300 g were divided randomly into 5 groups of treatment. After the necessary treatments tested on animals , blood and liver samples were collected . Activity of liver enzymes AST, ALT, ALP was measured . The microscopic sections were prepared from the liver and the pathological tissue was investigated .
Findings: Activity of liver enzymes (ALT, AST, ALP) in the diabetic group compared to non-diabetic controls showed a significant increase (pDiscussion & The findings showed that the extract of parsley leaves in diabetic rats can modulate the activity of the hepatic enzymes. Healing effect of the extract in the case of diabetes on liver histopatology was remarkable. The pharmacological properties and antiinflammatory protective effect of the parsley might be used to prevent hepatitis caused by diabetes.