Studying the Effects of Nanoparticle Cu on Function and Tissue Kidney in Wistar Rat

Since copper nanoparticles are one of the first nanoparticles programs in the industry, its adverse effects has increased on humans. The current research studies the effect of copper nanoparticles on some biomarkers of renal and its tissue.
A total of 32 Wistar rats were randomly divided into 4 groups: control (treated with .5 cc normal saline) and three experimental groups. Group 1, 2 and 3 received .5 cc of solution containing 10,100,300 ppm Cu nanoparticle via IP injection for 7 successive days, respectively. The effects of nanoparticles Cu on serum biochemical levels serum BUN (blood urea nitrogen), uric acid and ceratinin were evaluated at various time points (1, 7 and 14 days). After 14 days, the tissue kidney was collected and investigated.
Findings: According to the results, the creatinine levels between groups 3, 4 with control group differed significantly in the first week and group 2 with control group , in the second week was observed, respectively. All histological results indicate: complete destruction of the tubules in the renal cortex and destruction renal of renal of corpuscular in the group 2(impact effect of nanoparticle)- slight pathological changes in group 3 and the absence of pathological changes in group 4.
Discussion & According to the results, it can be concluded that the use of copper nanoparticles of spherical shape and 10-15 nm size, slightly was affected on renal factors and sever pathologic changes in the kidney tissue (low dose, 10nm).