The Combined Effect of Endurance Training and Atorvastatin on the Extent of Necrosis Damageand Fibrosis Tissue in Male Wistar Rats Heart after Experimental Myocardial Infarction

It has been known that both statins and exercise have beneficial effects in preventing cardiovascular diseases; however, there is no information about their combined effects on the amount of tissue damage after myocardial infarction. The purpose of this study was to evaluate the combined effect of endurance training and atorvastatin on the extent of necrosis and fibrosis tissue in rat hearts following myocardial infarction.
45 rats (8-10 weeks old, 230 ± 10 g body weight) were randomly divided to five groups. Sham, control, endurance training, atorvastatin, and exercise 櫚⽪쭚똩. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. Drug and training intervention was initiated 2 days after infarction and continued for 4 weeks. In order to assess the necrosis lesion and fibrosis tissue, Hematoxylin – Eosin and massontrichrome staining were used
respectively. Data were analyzed using oneway analysis of variance (ANOVA) at PFindings: The combination of endurance exercise and atorvastatin significantly reduced the amount of necrosis and fibrosis tissue compared with the control group (PDiscussion & results of this study showed that the combination of training and atorvastatin are more effective in improving tissue damage caused by myocardial infarction than exercise and atorvastatin alone.