Oral Schwannoma: A Systematic Review of the Case Reports

Schwannomas are benign neoplasms with unknown etiology, which apparently arise from neural sheath Schwann cells. Intraoral schwannomas are solitary, slow-growing lesions occurring at different ages; these lesions are normally asymptomatic and in some cases, they are accompanied by pain and paresthesia if spotted in the intraosseous regions of the mandibles. Definitive diagnosis of schwannoma is established through histopathological examination and immunohistochemical evaluation, and the first-line treatment involves the surgical excision of the tumor with preservation of neighboring structures. Anti-S100 protein is the most significant antibody used to identify schwannomas. Schwannomas are known to have good prognosis, and if the lesion is completely removed, there is a low risk of recurrence. This systematic review aimed to determine the most significant variables influencing intraoral schwannoma and evaluate effective methods for the diagnosis and treatment of these tumors.