Seroprevalence of Cytomegalovirus and Herpes Simplex Virus in Patients with Coronary Artery Diseases (CAD)

Ischemic heart disease implies reduction of oxygen and blood supply in the myocardium. The most common cause of ischemia is atherosclerotic coronary artery disease. While numerous risk factors lead to coronary diseases, the mechanism of infectious agents in CAD remains unidentified.
In this study, 360 patients with and without coronary disease underwent evaluation in terms of cytomegalovirus (CMV) and herpes simplex virus (HSV) seroprevalences. Serology was performed by means of ELISA assays.
Of 360 patients, positive serology was reported for CMV and HSV in 91.7 % and 93.3% with CAD as well as 66.1 % and 57.5 % without CAD (P Owing to possible association of viruses and bacteria in the process of atherosclerosis, furthur research is recommended to find out the relationship of other infectious agents with CAD and the presence of microorganisms in the coronary atherosclerotic specimens.