Comparative Study of Four Ion Selective Membrane Electrodes for Potentiometric Determination of Ivabradine Hydrochloride in Pharmaceutical Formulations and Plasma

Four different polyvinyl chloride (PVC) membrane sensors were investigated for the determination of ivabradine HCl in pure drug substance, pharmaceutical formulations and plasma. These sensors were fabricated using sodium tetraphenyl borate (TPB) [sensor 1a,1b,1c] or ammonium reineckate (RNC) [sensor 2a,2b] or sodium phosphotungestate (PTA) [sensor 3a,3b] or tetrakis(4-chlorophenyl)borate (TpClPB) [sensor 4a,4b] as ion exchanger. The proposed sensors showed fast and stable nernstian response range from 55.159.8 mV/decade across a concentration range 10-5-10-2 M in pH range 4.5-7.5. These electrodes exhibit good selectivity for ivabradine HCl with respect to a large number of inorganic, organic cations, sugars and amino acids. The results were statistically compared with a reported method. The comparison showed no significant difference between the proposed methods and the reported method regarding both accuracy and precision.