Immune Rebound: Multiple Sclerosis after Treatment of Cushing's Disease

High cortisol level in endogenous Cushing’s syndrome suppresses the immune system
and after treatment there may be an over activity of immune reaction leading to
autoimmune diseases mostly thyroid and rheumatologic disorders. This is the second
reported case of multiple sclerosis developing after treatment of Cushing’s syndrome. A
42-year old man is reported who presented with bone fracture and osteoporosis and
diagnosed with Cushing’s disease. Six months after surgical treatment of his pituitary
adenoma, he developed progressive multiple sclerosis. We conclude that after treatment
of endogenous Cushing’s syndrome, the patients should be watched for development of
autoimmune disorders including those affecting the central nervous system.