Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male toxicated by anabolic steroid

Aim: Effect of zizyphus jujube extract and resistance exercise on liver damaging biomarkers in male rats toxicated by anabolic steroid.
42 Wistar rats were randomly divided into six equal groups: group 1: control, group 2: sham, group 3: anabolic steroid (5 mg/kg), group 4: anabolic steroid (5 mg/kg) zizyphus jujube extract (600 mg/kg), group 5: anabolic steroid (5 mg/kg) resistance exercise, and group 6: anabolic steroid (5 mg/kg) zizyphus jujube extract (600 mg/kg) resistance exercise. Apart from the control and sham groups, anabolic steroid with a 5 mg per kg dose was injected to other groups once a week. The resistance exercise protocol were consisted of three exercise sessions per week by 5 repetitions in 3 sets of climbing ladder for eight weeks. The data were analyzed by the SPSS software, using ANOVA.
The results of this study revealed a significant increase in liver enzymes (ALT, AST, and ALP) and direct and total bilirubins in the anabolic steroid group (group 3) compared to the control and sham groups (p : Zizyphus jujube extract consumption as well as resistance exercise caused a significant decrease in liver damaging biomarkers. Hence, the simultaneous use of resistance exercise and zizyphus jujube extract did not show any increasing effect on these biomarkers.