Effect of grape seed extract on improving memory and learning impairment induced by streptozotocin in male rat
Author(s):
Abstract:
Background And Objective
Alzheimer's disease is an age-related disease that is characterized by dementia and loss of neurons in the brain. It has been shown that brain oxidative stress plays an important role in aging and neurodegenerative disorders. This study was done to evaluate the effect of grape seed extract (GSE) on memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in animal model of Alzheimer's disease.Methods
In this experimental study, Eighty adult male Wistar rats were randomly allocated into control, sham, grape seed extract (100 mg/kg/bw, 30 days, orally) plus STZ and STZ plus grape seed extract. Animals memory were evaluated using Morris water maze, shuttle box and T maze tests.Results
Intracerebroventricular injection of STZ caused memory corruption in all tests. Administration of GSE before and after of administration of intracerebroventricular STZ in the Morris water maze test, significantly reduced latency to get to the hidden platform compared to Alzheimer's group (PConclusion
Grape seed extract has important effect in prevention and improving memory impairment induced by intracerebventricular injection of STZ.Keywords:
Alzheimer , Grape seed , Streptozotocin , Rat
Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:18 Issue: 2, 2016
Pages:
27 to 34
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