Evaluation of frequency polymorphism Interleukin B1 gene in patients with peptic ulcer and chronic gastritis

Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1B gene.
107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-1B�砋 polymorphism was analyzed through PCR-RFLP.
There is no association between the presence of the T allele in an IL-1B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66, CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively.
Our results suggest that there is no association between IL-1B� C/T polymorphism and peptic ulcer disease and chronic inflammation.