The protective effects of Curcuma longa extract on oxidative stress markers in the liver induced by Adriamycin in rat

The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat.
Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR嘫), Vitamin C (Vit C), C. longa with Adriamycin (CL4) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg and rats were treated with C. longa 1000 mg/kg and Vitamin C 100 mg/kg , per day, orally for 4 weeks.
In the liver tissue of ADR group, Malonyldialdehyde (MDA) level was increased significantly compared to CO group, (p The results showed that chronic administration of C. longa hydroalcoholic extract in Adriamycin-induced hepatotoxic rats could decrease the oxidative stress injuries in the liver tissue.