Genetic Variations in Leptin and Leptin Receptor and Susceptibility to Colorectal Cancer and Obesity
Author(s):
Abstract:
Background
Colorectal cancer (CRC) is the second most commonly diagnosed cancer and the fourth leading cause of cancer-related mortality around the world.Objectives
With regard to the role of obesity in colorectal cancer (CRC) and the role of leptin in obesity, we investigated whether leptin (LEP) and leptin receptor (LEPR) gene variants are associated with CRC risk.Patients and
Methods
We evaluated LEP (rs7799039) and LEPR (rs1137101) gene variants by using PCR-RFLP method in 261 cases with CRC and 339 controls.Results
No significant difference was found for rs7799039 and rs1137101gene variants between the cases with CRC and controls. However, the LEPR rs1137101 GG genotype compared with AA genotype and AA AG genotype was associated with increased risks for obesity, and the differences remained significant after adjustment for confounding factors including age, sex, smoking status, and NSAID use (P = 0.015; OR = 2.42, 95%CI = 1.19 - 4.93 and P = 0.016; OR = 2.28, 95%CI = 1.17 - 4.48, respectively). In addition, the LEPR G allele compared with the A allele was associated with an increased risk for obesity (P = 0.024; OR = 1.44, 95%CI = 1.05 - 1.98).Conclusions
Consistent with most previous studies, our findings found no association between LEP (rs7799039) and LEPR (rs1137101) gene variants and CRC risk. However, the LEPR rs1137101 GG genotype compared with the AA genotype and AA genotype was associated with a 2.42-fold and a 2.28-fold increased risk for obesity, respectively. Keywords:
Colorectal Cancer , LEP , LEPR , Variant
Language:
English
Published:
International Journal of Cancer Management, Volume:9 Issue: 3, Jun 2016
Page:
4
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