The effect of acute resistance exercise on serum levels of some inflammatory and muscle damage markers in inactive women

Studies have reported conflicting results regarding the acute effects of exercise on inflammatory, oxidative stress and muscle damage parameters. Therefore, this study aimed to investigate the effect of acute resistance exercise on serum levels of tumor necrosis factor alpha (TNF-α), as a marker of inflammation, malondialdehyde (MDA), as a marker of oxidative stress, and levels of lactate dehydrogenase (LDH) and creatine kinase (CK), as two markers of muscle damage.
For this purpose, 20 healthy and inactive women (age, 21.55.56 year; BMI, 21.68.26 kg/m2) were randomly divided into acute resistance exercise and control groups. The subjects performed one bout of acute resistance exercise with 85% of one-repetition maximum (1RM) at 8 stations (bench press, leg press, seated rows, overhead press, seated leg press, arm extension, arm curls and calf raises), each exercise were done for 3 sets. Blood samples were taken before and immediately after exercise. TNF-α and MDA levels were measured using ELISA method by commercial kits. Moreover, LDH and CK were measured by photometric method. Paired sample t-test and independent t-tests were used to analyzed dependent variable within and between groups, respectively (p One bout of acute resistance exercise had significant increases (p 0.001) in serum levels of TNF-α and MDA. Also, serum levels of muscle damage parameters, LDH (p=0.03) and CK (p=0.001), showed significantly increases following acute resistance exercise.
One bout of intense resistance exercise is associated with oxidative and muscle damage in inactive women, therefore adoption of training and nutritional approaches are essential when implementing with this kind of exercise.