Additive effects of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice

Resveratrol is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases. This study was done to evaluate additive effect of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice.
In this experimental study, 56 Swiss Webster male mice were randomly allocated into 6 groups including negative control group (normal saline), positive control (imipramine (10 mg/kg/bw), experimental groups; trans resveratrol (10 mg/kg/bw), Imipiramine (10 mg/kg/bw) and mixtures (with ratio of 1:1 of resveratrol with imipramine (2.5 mg/kg/bw, 5 and 10 mg/kg/bw), intraperitoneally. The forced swimming test has been done for all groups. Through swimming of animals in water, the immobilization times of animals as depressive symptom were recorded.
The immobilization times significantly reduced in animals which were received imipramine 10 mg/kg/bw in compare to control group (P According to additive effect of imipramine with resveratrol we can suggest resveratrol in combinations with other antidepressants to lower their doses and related side effects of chemical drugs.