Natural Killer Cell Subsets and IL-2, IL-15, and IL-18 Genes Expressions in Chronic Kidney Allograft Dysfunction and Graft Function in Kidney Allograft Recipients
Author(s):
Abstract:
Background
While acute rejection and early graft loss rates have decreased substantially over the past four decades, progressive chronic allograft dysfunction (CAD) still remains a common cause of late graft loss in kidney transplant recipients.Objective
This study was conducted to investigate the percentage of natural killer (NK) cell subsets and IL-2, 15 and 18 genes expression in two groups of CAD and well-function graft (WFG) recipients.Methods
30 renal allograft recipients with biopsy-proven interstitial fibrosis/tubular atrophy (IF/TA) and impaired renal function, and 30 sex- and age-matched WFG patients were enrolled in this study. The percentage of NK cell subsets including NK CD56bright and NK CD56dim cells were determined by flowcytometry; IL-2, IL-15, and IL-18 genes expressions were assessed by real-time PCR.Results
Compared to WFG patients, there was a significant (pConclusion
We found higher percentages of NK CD56bright subset in kidney transplant recipients with CAD without considerable changes in related cytokines gene expression, suggesting a possible defect of NK cells maturation in these patients.Language:
English
Published:
International Journal of Organ Transplantation Medicine, Volume:7 Issue: 4, Autumn 2016
Page:
212
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