Histological disorders of brain in cultivated orange spotted grouper Epinephelus coioides from Bandar Emam Khomeini

Epinephelus coioides fish is cultivated in Emam Khomeini Fisheries Research Center under Southern Aquaculture division. This fish is used in histology, histopathalogy, toxicology, physiology, cellular and molecular biology, studies. The Zangi creek water is contaminated due to petrochemical, industrial, agricultural and commercial communication pollutants. The water that the fish are cultivated with is obtained from Zangi creek and the fish which are exposed to this water are contaminated. In the histopathological experiments performed by Haemotoxylin- Eosin staining method in the brain, disorders such as karyolysis and necrosis of the nucleus, vaculation and oedema as well as hyperanemia are apparent. These defects are more obvious in the medulla oblongata, diencephalon and cerebellum of the brain. These disorders could be due to contamination of Zangi creek water such as heavy metals, organic derivatives of heavy metals, aromatics, organophosphates and etc.