Study of some Biochemical and Hematological Parameter Changes in Rats Induced by Intraperitoneal Injection of Colloidal Silver Nanoparticles
Author(s):
Abstract:
Background And Objective
Today, silver nanoparticles are used extensively in various fields, especially in the control of bacterial infections. However, the toxicity of silver nanoparticles is a very important concern in their use. The aim of this study was determining the effect of the intraperitoneal injection of colloidal silver nanoparticles on biochemical and hematological parameters in rats.Materials And Methods
In this experimental study, 21 adult female rats were randomly divided into 7 groups. Group 1 was sham. Group 2 was a control group and group 3 to 7 were case groups that were treated with 5, 10, 20, 40 and 80 ppm of silver nanoparticles, respectively. Mice treated for 10 days. On the eleventh day the rats were killed by diethyl ether anesthesia. Blood samples were taken from the heart. Then the biochemical and hematological parameters and lactate dehydrogenase (LDH) levels evaluated.Results
The results showed no significant changes in biochemical factors except triglycerides (TG), which showed a significant decrease in high concentrations of silver nanoparticles (pConclusion
Low concentrations of silver nanoparticles (such as injecting it inside the peritoneum) has no effect on biochemical parameters in rats. By studying any other possible side effects, it may be safe to use in various industries.Keywords:
Language:
Persian
Published:
Journal of Advances in Medical and Biomedical Research, Volume:25 Issue: 108, 2017
Pages:
120 to 128
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