The Association of 4G/5G Polymorphism of PAI-1-675 Gene with Clinicopathologic Features of Thyroid Tumors in Iranian Azeri Turkish Patients

Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients.
In this case-control study, 90 patients with thyroid tumors who were not blood relatives and their PAI-1 4G/5G polymorphism had been determined in the previous study, were included.
All clinicopathologic features of thyroid tumor related to PAI-1 4G/5G polymorphism that affect the severity of disease were studied. The results show that T1 tumor size (4G/4G, P = 0.019; 4G/5G, P = 0.021) in patients with/without these features was significantly different.
Data showed a protective role for 4G allele versus 5G and 4G/4G versus 5G/5G against the development of thyroid tumors in Azeri Turkish ethnic group.