Voice Acoustic and Perceptual Features in Lipoid Proteinosis: A Report of Two Cases

Background and Lipoid Proteinosis (LP) is a rare hereditary progressive disorder caused by a disorder of collagen metabolism. In LP, hyaline deposits in mucous membrane of true vocal folds causes hoarseness. The studies on the laryngeal and voice features of patients with LP are rare. To the best of our knowledge, this is the first research to study acoustic and perceptual voice features in two Iranian children with LP.
Two children (siblings) were assessed. The main voice complaint was hoarseness. Voice samples were recorded and acoustically analyzed by Praat. Furthermore, perceptual voice assessment was performed according to the GRBAS scale.
Acoustic measurement represented increase in f0, jitter, and shimmer in both children. Furthermore, mean scores of the GRBAS for all voice parameters were more than 60.
Current study is the first research that describes the voice features of Persian subjects with LP. Comprehensive understanding of the etiology in voice problems helps speech and language pathologists to provide appropriate clinical services considering the nature of pathological condition to clients.