The effect of garlic supplementation on inflammatory and enzymatic indices of oxidative stress response after an incremental aerobic exercise exercise

Aim: The present study was carried out to determine the effect of garlic supplementation on some inflammatory indices following exhaustive aerobic exercise in sedentary female.
Nineteen volunteer sedentary young females (age 23.15±2.65 years, BMI 22.93±1.25 kg.m2,VO2max 30.36±4.5 persent and bruce time 7.82±1.03) were assigned to a randomized and double-blind into two equal garlic (n=10) and placebo (n=9) groups.
After 14 consecutive days supplementation (500 mg garlic or lactose every 12 hours a day), all subjects were participated in incremental aerobic exercise protocol (Bruce test). Changes in inflammatory and enzymatic markers were determined in four phases (before supplementation phase, before exercise, immediately and 24 hours after the aerobic exercise).
Data were analyzed by repeated measure and independent T test at P≤0.05.
The results showed that one session of exhaustive aerobic exercise significantly increased some of the inflammatory and oxidative stress markers, in both groups (P≤0.05). Also, garlic supplement can decrease Hs-crp, Lymphocyte, Neutrophil, AST and ALT levels immediately after exercise protocol (P≤0.05). But other markers (total WBC, IL-6, LDH, CPK) were not changed significant.
The results of this study showed that the garlic supplementation leads to decrease some of inflammatory and enzymatic indices of oxidative stress. Therefore, based on the present results, garlic supplementation can reduce the oxidative stress markers ranges following the exhaustive aerobic exercise.