Evaluation of pulse and continues administration of Enrofloxacin on serum biochemical indices and performance in colibacillosis infected broilers

To reduce the losses caused by the E. coli, antimicrobials widely used in the poultry industry. The aim of this study was to compare pulse and continues administration of the Enrofloxacin on the performance and biochemical parameters were caused by colibacillosis. Four hundred and fifty colibacillosis infected broiler chickens was selected and distributed in 3 groups of 150 chicks and each with 3 replicates. In the first group Enrofloxacin was administrated 4 days continuously and in the second group it was administrated by pulse method 4 days and daily 8 hours and third group was as control. After treatment, 21 blood samples were taken from each groups, and by biochemical tests, the amounts of ALT, AST, total protein, ALP and creatinine was evaluated. White blood cells differentiated amount also were recorded. Gross lesions and clinical signs also evaluated during study period. For comparison the results Independent T-test and SPSS statistical software ver. 22.0 were used. Results indicated there was significant differences between the methods from AST and ALT aspect(p0.05). It was demonstrated that the pulse administration of Enrofloxacin has better outcomes in treatment of colibacillosis and also it was decreased costs of antibiotics usage in poultry production. Thus pulse administration suggested for treatment of colibacillosis.