All Solid Sate Potentiometric Sensors for Granisetron Hydrochloride in Pharmaceutical Formulation

Granisetron content of some pharmaceutical tablets was determined using a novel all-solid-state polymeric-membrane-electrode (ASS-PME) having a sensing element functioning based on an ion-exchange mechanism. The best results were observed with ASSPMEs containing 8% GST-tetrakis (p-chlorophenyl) borate as the ion-pair, 56% of dibutyl phthalate, 31% of poly(vinyl chloride), 3% of an ionic liquid and 2% of KpClTPB. The ASS element of the device was a conductive composite of graphite, MWCNTs, and an epoxy resin coated on a copper wire, and the PVC membranes were coated on the ASS. The ASS-PME showed a Nernstian response of 58.1±0.2 mV/decade over the range of 1.0×10-6 to 1.0×10-3 M. The application of the device was validated and the method was found to be applicable in the analysis of Granisetron hydrochloride in pharmaceutical formulations.