Inflammatory markers and muscle damage indices response to intense exercise in healthy boys: relationship between the markers

Based on the limited and inconsistent results in regarding to the effects of intense exercise on inflammatory markers and muscle damage in adolescents, the aim of this study was to examine the response and relationship between some inflammatory markers and muscle damage in 14-16 years old boys in response to incremental physical activity.
Twenty-four healthy 14-16 years old boys volunteered and divided in two groups as exercise (n=12) and control (n=12) groups. The exercise group performed incremental modified Balke protocol physical activity, according to the defined protocol. In order to examine the levels of plasma fibrinogen, Serum CRP and CPK blood samples were collected in baseline and immediately 2 minutes after incremental physical activity in trained group and also in baseline and 48 hours later in the controls group. To statistical analysis the dependent t-test, independent t-test, Pearson's correlation coefficient and beta coefficient were used and the significant level set at p Serum CRP (p=0.01), CPK (p=0.01) and plasma fibrinogen (p=0.01) levels significantly increased immediately after intense exercise in the exercise group (p