Application of Cu(II) Nanocomplex Modified Graphite Screen Printed Electrode to Improve the Sensitivity and Selectivity for Epinephrine Detection

A Cu(II) nanocomplex, [CuCl2(salophen)].H2O [salophen=ophenylenediaminebis(salicylidenaminato)], was synthesized. The electrochemical properties of the as-prepared Cu(II) nanocomplex modified graphite screen printed electrode (Cu/SPE) were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Moreover, as a nanosensor for the determination of epinephrine the Cu/SPE exhibited excellent electrocatalytic activity for the oxidation of epinephrine with a faster electrontransfer rate. The DPV technique was used for the trace determination of epinephrine. The dependence of current vs. concentration was linear from 10.0 to 600.0 μM with a regression coefficient of 0.9975, and the detection limit of epinephrine was 2.5±0.05 μM. Finally, the method was applied to the selective and precise analysis of epinephrine in epinephrine injection.