The Effect of regular aerobic exercise with vitamin C consumption on the homocysteine levels and insulin resistance in obese girls

Childhood obesity is associated with an increased risk for several metabolic and cardiovascular complications, such as insulin resistance and hyperhomocysteinemia .The aim of this study was to investigate the effect of regular aerobic exercise with vitamin C consumption on the homocysteine levels and insulin resistance in obese girls.
In the present semi-experimental study, 28 obese girls aged between 8 and 12 Years and body mass index 95th percentile, were selected and randomly divided into as follow: control, exercise training, vitamin C and exercise training vitamin C (combined) groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions per week for 8 weeks. Vitamin C and combined groups consumed 500mg vitamin C tablets every other day. Fasting blood samples were collected before and 48 hour after the last intervention. For statistical analysis, One Way Analysis Variance (ANOVA), post hoc Tukey and independent t-test were used.
Eight weeks of aerobic exercise, vitamin C and the combined intervention were resulted a significant decrease in the levels of glucose, insulin, homocysteine and insulin resistance in obese girls (P These findings suggest that both of aerobic exercise and vitamin C consumption non-drug can cause down regulation of homocysteine and insulin resistance levels in obese girls. Thus combined effect of regular aerobic exercise and vitamin C intervention is associated with the augmentation of these effects.